Colon
Inflammatory disease
Ulcerative colitis
is confined to the colon and rectum. You might see occational ileal involvement, so-called "backwash" inflammation.- Crypt distortion/Architectural distortion
- inflammation confined to the mucosa and submucosa
- might see thickening of the muscularis mucosae
- Basal plasmocytosis
- no granulomas, fissures are not seen and fibrosis is usually absent
Crohn disease
Can be found anywhere from the mouth to anus, and has a patchy distribution. There is often an ileum involvement.- Crypt distortion/Architectural distortion
- Transmural inflammation
- Granulomas
- fibrosis
- fissures are common
- Paneth cell or pyloric gland metaplasia