Borderine tumors
Borderline tumors are most often found in the ovaries, and only
seldom in the uterine tube or peritoneum. The tumors are made out
of atypical epithelium without stromal invasion. Serous, mucinous,
endometrioid, clear cell, seromucinous and brenner are all
different subtypes of borderline tumors.
Serous borderline tumors
Microscopy
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Can be cystic or solid masses with surface papillary
epithelial structures.
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The epithelium is made out of cuboidal to columnar cells with
pseudostratification, often with hobnailing or tufting.
(Should cover >10% of the epithelium).
mild-to-moderate nuclear atypi
- Detached cells, that can be round and eosinophilic.
- Sometimes you will see Psammoma bodies.
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Immunohistochemistry: P53 (wild-type), P16 (negative or
patchy), WT1 (positive), ER (positive), CK7 (positive), CK20
(negative).
