Cervical intraepithelial neoplasia (CIN)
- CIN1 (low grade SIL):
Dysplasia and mitosis in the lower
1/3
of the epithelium
Koilocytes:
Cells in the epithelium with perinuclear halo, increased
nuclear size and wrinkled, raisin-like, nucleus with
hyperchromasia.
You might see:
Binucleated or even multinucleated cells, that tend to be the
same size as the other affected cells.
Dyskeratotic cells (cells with keratinization)
- CIN2 (high grade SIL):
Dysplasia and mitosis in the lower
2/3
of the epithelium.
- CIN3 (high grade SIL):
Dysplasia and mitosis in
3/3
of the epithelium
Basal cell hyperplasia
Is the growth/hyperplasia of the basal layer of the squamous
epithelium, without nuclear pleomorphism. Ki67 and p16 are useful to
distinguish basal cell hyperplasia from CIN.
